Rome is thecapital of Italy and of its Latium region. It is located across the confluence of thetiber and Aniene rivers. It was once the capital of the Roman Empire, the most powerful, largest, and longest lasting empire of classical antiquity. Rome is the largest city and commune in Italy and it is also one of the largest among European capital cities. Many international headquarters, government ministries, conference centres, sports venues and museums are located in Rome's principal business districts.